Castlevania: Mirror of Fate is coming to the 3DS in 2013, and David Cox has explained why the game is specifically on its way to this platform:

We knew we wanted to do a game on a handheld. Castlevania has traditionally done well on handhelds. And when we looked at different formats, we really liked the 3DS because we knew we could do a really cool 2.5D side-scroller, but with 3DS we had the advantage of layers and layers of 3D and using the stereoscopic camera to go into the world; a dynamism that wouldn’t be on other handhelds. And once we got hold of the hardware, we realised what we could do with it. We essentially built an engine from the ground up for the 3DS, we felt that this was the right format.

Sounds like a perfect match.